Abstract
BackgroundNon-ischemic dilated cardiomyopathy (DCM) is the most common cardiomyopathy worldwide, with significant mortality. Correct evaluation of the patient's myocardial function has important clinical significance in the diagnosis, therapeutic effect assessment and prognosis in non-ischemic DCM patients. This study evaluated the feasibility of three-dimensional speckle tracking imaging (3D-STE) for assessment of the left ventricular myocardial strain in patients with non-ischemic dilated cardiomyopathy (DCM).MethodsApical full-volume images were acquired from 65 patients with non-ischemic DCM (DCM group) and 59 age-matched normal controls (NC group), respectively. The following parameters were measured by 3D-STE: the peak systolic radial strain (RS), circumferential strain (CS), longitudinal strain (LS) of each segment. Then all the parameters were compared between the two groups.ResultsThe peak systolic strain in different planes had certain regularities in normal groups, radial strain (RS) was the largest in the mid region, the smallest in the apical region, while circumferential strain (CS) and longitudinal strain (LS) increased from the basal to the apical region. In contrast, the regularity could not be applied to the DCM group. RS, CS, LS were significantly decreased in DCM group as compared with NC group (P < 0.001 for all). The interobserver, intraobserver and test-retest reliability were acceptable.Conclusions3D-STE is a reliable tool for evaluation of left ventricular myocardial strain in patients with non-ischemic DCM, with huge advantage in clinical application.
Highlights
Non-ischemic dilated cardiomyopathy (DCM) is the most common cardiomyopathy worldwide, with significant mortality
Conventional echocardiography Age, gender, BSA and heart rate showed no significant difference as compared with NC group (P > 0.05), while LVDd, LVEDV, LVESV, left ventricular ejection fraction (LVEF), LVEDVI, and LVESVI decreased significantly in DCM group (P < 0.01, Table 1)
radial strain (RS), circumferential strain (CS) and longitudinal strain (LS) of each segment were significantly decreased in DCM group as compared with NC group (P < 0.001 for all, Tables 2, 3, 4)
Summary
Non-ischemic dilated cardiomyopathy (DCM) is the most common cardiomyopathy worldwide, with significant mortality. Correct evaluation of the patient’s myocardial function has important clinical significance in the diagnosis, therapeutic effect assessment and prognosis in non-ischemic DCM patients. This study evaluated the feasibility of three-dimensional speckle tracking imaging (3D-STE) for assessment of the left ventricular myocardial strain in patients with non-ischemic dilated cardiomyopathy (DCM). The research on myocardial function in patients with non-ischemic DCM has become a hot topic in cardiovascular ultrasound [4,5,6], which mainly based on tissue Doppler imaging and two-dimensional speckle tracking imaging. Even though two-dimensional speckle tracking imaging solves this problem but it is limited by a more difficult detection of LV movement, because it can not assess movement in the third dimension [7]
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