Preliminary clinical outcome in patients with glioblastoma treated with precise radiotherapy plus concomitant temozolomide

Abstract

Objective To investigate the clinical outcomes and toxicity for patients with glioblastoma multiforme (GBM) who underwent precise radiotherapy combined with temozolomide (TMZ).Methods The records of 54 patients with newly - diagnosed GBM from July 2009 to December 2010 were reviewed.The patients underwent postoperative intensity - modulated radiotherapy (IMRT) or three -dimensional conformal radiotherapy (3D -CRT) with concurrent and adjuvant TMZ.Results The median follow - up was 13 months.Of the 54 patients,50 completed the combined modality treatment.The overall survival rate was significantly different between patients with good performance status( KPS ≥70) and those with worse performance status ( KPS ＜ 70) ( 86.8％ VS.50.8％,P =O.005 ).Patients who underwent partial resection had lower overall survival rate compared with those who underwent total resection,but no reach statistically significant (84.4％ vs.70.5％,P =0.067).The pattern of failure was predominandy local. Grade 3 -4 toxicity was limited to 2 patient with leukopenia during concurrent chemoradiotherapy.Conclusions These results indicate that precise radiotherapy combined with TMZ is effective and safe treatment for GBM patients. Performance status and extent of surgery were prognostic factors for overall survival. Key words: Glioblastoma, multiforme; Three -dimensional conformal radiotherpy; Intensity -modulated radiotherapy; Temozolomide