Abstract
Objective To evaluate the clinical value of radioimmunoimaging (RII) in diagnosis of breast cancer using 99Tcm labeled antimucin monoclonal antibody. Methods 17 patients with various breast tumors underwent RII. Results 8 of 9 patients with primary breast cancer gave positive results of RII, with the sensitivity of 88.89%. Ipsilateral lymphatic metastasis was detected in 4 of 5 patients with primary breast cancer plus axillary lymph node involvement and for the remaining 1 patient contralateral lymph node metastasis was detected; the patient received mastectomy 5 years ago due to breast cancer of that side. RII results of the remaining 7 patients were negative, they were 6 patients with benign breast tumour and 1 followedup patient who underwent mastectomy 7 years ago due to breast cancer. Conclusions RII using 99Tcm labeled antimucin McAb can be used as a valuable method in the diagnosis of primary breast cancer, lymph node metastases and recurrence. Key words: Antibodies, monoclonal; Antibodies, neoplasm; Mucins; Breast neoplasms; Radioimmunodetection
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