Abstract
Leptospirosis is a global zoonotic disease caused by pathogenic Leptospira, and those infected animals will show a variety of clinical symptoms and even death. The discovery of endemic strains is crucial to produce effective vaccines. In this study, we report that a strain of Leptospira, isolated from a dog, is pathogenic. Using MLST analysis, the serovar of isolated Leptospira was identified and found it belongs to Leptospira interrogation Serovar Australis. Then, the virulence of this strain was researched by using hamsters. After infection, all the hamsters died within 4–5 days. Typical pathological changes were found in the liver, kidney, and lung of hamsters. These results all indicated that the isolated Leptospira was pathogenic. Thus, this study facilitates to identifying local Leptospira strains and develop a more targeted canine Leptospira vaccine.
Highlights
Leptospirosis, caused by a pathogenic Leptospira, is a zoonotic disease
The dog, we studied in this study, has clinical symptoms of vomiting, loss of appetite, and jaundice, which is like the symptoms of Leptospirosis
The results showed that a band appears at 468 bp,it was Leptospira interrogans (Figure 2B)
Summary
Leptospirosis, caused by a pathogenic Leptospira, is a zoonotic disease. Human may get leptospirosis directly or indirectly from animals [1]. Leptospirosis occurs worldwide, especially in tropical and subtropical regions where rains a lot. Preliminary results indicate that the currently incidence of Leptospirosis may give rise to a serious underestimation of actual cases. This underestimation is partly due to the no characteristic manifestations in Leptospirosis, which are often confused with other diseases that is prevalent under similar environmental and climatic conditions, such as dengue fever, rickettsia disease, enteritis, and malaria [4]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
