Abstract
Preliminary biochemical studies were carried out to demonstrate for the first time a Mg 2+-ATPase associated with those hamster sperm head membranes released by the acrosome reaction in vitro . The enzyme is inhibited by two common inhibitors of proton-translocating ATPases of mitochondria and other somatic cell organelles. These inhibitors have also been previously shown by us to raise the intraacrosomal pH in hamster sperm under certain conditions. Addition of low levels of calcium also inhibited the enzyme. These results together with our previous work suggest the involvement of an ATPase proton pump in acidification of the hamster sperm acrosome.
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