Abstract
Resistance to anthelmintic drugs has become a big challenge in developing nations as well as developed countries. According to WHO only few drugs are available till yet for the treatment of helminth infection. Helminths can affects an y age group of person whether it may be a child or adult. Punica granatum is a fruit bearing plant of family Punicaceae which aims for the treatment of Helminthesiasis, Its English name is Pomegranate. In ancient time its various parts were used to treat m any kind s of ailments. In the present study the Punica granatum fruit extracts of two varieties were taken to explore comparative anthelmintic potential. The two were Punica granatum Nashik (India) and Punica granatum Kandhari (Afgan) . Isolation and extrac tion of peel, seed and juice of both varieties were done in laboratory. O nly ethanolic extract of Epicarp and seed were taken. It was found that the Epicarp of Nasik variety has great pote ntial for anthelmintic activity and juice possesses no anthelmintic activity. Albendazole, Piperazine citrate and Pyrantel pamoate were taken as standard drugs. Dose of all extract s and standard drugs were taken as 20 mg/ml for in vitro study.
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