PREIMPLANTATION GENETIC TESTING (PGT) SIGNIFICANTLY INCREASES IMPLANTATION AND LIVE BIRTH RATES IN PATIENTS OF ALL AGE GROUPS UNDERGOING IVF

Abstract

To study whether PGT improves embryo implantation and live birth in patients undergoing IVF. The SART National Summary Reports from 2014 to 2017 were used for this study. Cycle inclusion criteria were day 5/6 elective single embryo transfers (eSET), fresh embryo transfers (ET), the first frozen embryo transfers without PGT (FET) or with PGT (FET/PGT). Exclusion criteria were use of gestational carriers and donor eggs/embryos. Clinical outcomes included embryo implantation, live birth, and miscarriage rates. X2 tests were used for statistical analysis. A total of 101,266 eSETs were analyzed for the effect of PGT on IVF outcomes including 43,618 ET, 17,511 FET and 40,137 FET/PGT cycles. Rates of both live birth and implantation were significantly higher in patients with FET/PGT than those in the ET and FET groups in both < 35 and ≥ 35 age groups (P < 0.0001, Table 1). There was no statistical difference in miscarriage rate between FET/PGT and ET in the < 35 age group, but miscarriage rate in the FET/PGT was significantly lower in the ≥ 35 age group (FET/PGT, 13.0% vs ET, 18.9% and FET, 20.5%).Table 1Clinical outcomes in patients undergoing IVF with or without PGTOutcome< 35> 35ETFETFET/PGTETFETFET/PGT# of transfers31,90312,58117,53711,7154,93022,600Live Births, %49.651.756.637.641.055.0Miscarriage rate, %11.814.911.618.920.513.0Implantation rate, %55.658.762.345.248.861.2P valuesPGT vs ETPGT vs FETFET vs ETPGT vs ETPGT vs FETFET vs ETLive Birth rate, %<0.0001<0.0001<0.0001<0.0001<0.0001<0.0001Miscarriage rate, %0.52<0.0001<0.0001<0.0001<0.00010.09Implantation rate, %<0.0001<0.0001<0.0001<0.0001<0.0001<0.0001 Open table in a new tab This study using large cohort SART data demonstrates that PGT not only significantly increases live birth and embryo implantation in the patients 35 or older, but also in the patients younger than 35.