Abstract
Inherited cancer predisposition is presently one of the major indications for preimplantation genetic testing (PGT), providing an option for couplers at risk to avoid the birth of an offspring with predisposition to cancer. We present here our experience of 874 PGT cycles for cancer, resulting in birth of 387 mutation free children, without risk of developing cancer, which is a part of our overall PGT series of 6,204 PGT cases for monogenic disorders (PGT-M), with 2,517 resulting births, free of genetic disorder. The accumulated experience demonstrates considerable progress in using PGT for avoiding the birth of children with genetic predisposition to cancer.
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