Abstract
Pretreatment of female rats with pregnenolone-16α-carbonitrile (PCN) for 2 1 2 days resulted in a significant increase in cytochrome P-450 content and NADPH-cytochrome c reductase activity in hepatic microsomes. The spectral characteristics of the microsomal hemoprotein from PCN-treated rats were similar to those obtained from untreated and phenobarbital (PB)-treated rats but different from 3-methylcholanthrene (3-MC)-treated animals. However, the specificity of the induction effect of PCN on the oxidative metabolism of benzphetamine, ethylmorphine, and 3,4-benzpyrene differed from the specificity of either PB or 3-MC. Studies on the induction of enzymes that metabolize the above three substrates revealed that PB, PCN, and 3-MC exerted their greatest stimulatory effect on benzphetamine N-demethylation, ethylmorphine N-demethylation, and 3,4-benzpyrene hydroxylation, respectively.
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