Pregnant Pause: Does Maternal PBDE Exposure Extend Time to Pregnancy?

Abstract

Vol. 118, No. 5 NewsOpen AccessPregnant Pause: Does Maternal PBDE Exposure Extend Time to Pregnancy? Julia R. Barrett Julia R. Barrett Search for more papers by this author Published:1 May 2010https://doi.org/10.1289/ehp.118-a217aCited by:1AboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Animal studies indicate polybrominated diphenyl ethers (PBDEs) are endocrine disruptors, potentially affecting the role of thyroid hormones in regulating the reproductive cycle and fertility. The compounds also have been associated with delayed puberty and altered estradiol levels in female animals. Very little is known about the potential effects of PBDEs on human reproductive health, though, and a new study is the first to characterize a specific concern—a relationship between PBDE blood concentrations and a delay in achieving pregnancy [EHP118:699–704; Harley et al.].PBDEs are used as flame retardants in furniture, carpeting, textiles, electronics, and plastics. Commercial mixtures of PBDEs contain a variety of congeners, or chemical variations. Data collected by the Centers for Disease Control and Prevention suggest 97% of Americans may have detectable levels of PBDEs in their blood.The current study included 223 pregnant women enrolled in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS), a longitudinal birth cohort study focused on environmental exposures and reproductive health in California’s Salinas Valley. Upon enrollment, the women reported their reproductive history, previous use of contraception and fertility medication, whether the pregnancy was planned, and how long it took to become pregnant after stopping contraception.Blood samples collected around 26 weeks of pregnancy were analyzed for 10 PBDE congeners. Statistical analyses focused on those most commonly found: BDE-47, BDE-99, BDE-100, and BDE-153. BDE-100 and BDE-153 were the most strongly associated with longer time to pregnancy. For each month, the likelihood of becoming pregnant was 40% or 50% lower with a 10-fold increase in concentration of BDE-100 or -153, respectively. With a 10-fold increase in the total of all 4 congeners, there was a 30% decrease in the odds of pregnancy each month.The study relied on self-reported time to pregnancy, which is subject to a number of biases. In addition, the study’s findings are limited to 4 PBDE congeners and may not extend to a broader population. Consequently, further research incorporating more congeners and a more representative population is needed. However, given the likelihood of PBDE exposure in the general population, even a small effect of these chemicals on fertility may affect a large number of individuals.FiguresReferencesRelatedDetailsCited By Gao Y, Chen L, Wang C, Zhou Y, Wang Y, Zhang Y, Hu Y, Ji L, Shi R, Cui C, Ding G, Jin J and Tian Y (2016) Exposure to polybrominated diphenyl ethers and female reproductive function: A study in the production area of Shandong, China, Science of The Total Environment, 10.1016/j.scitotenv.2016.07.181, 572, (9-15), Online publication date: 1-Dec-2016. Vol. 118, No. 5 May 2010Metrics About Article Metrics Publication History Originally published1 May 2010Published in print1 May 2010 Financial disclosuresPDF download License information EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. Note to readers with disabilities EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact [email protected]. Our staff will work with you to assess and meet your accessibility needs within 3 working days.