Abstract
Pregnancy specific β1 glycoprotein (SP-1) levels have been suggested to correlate with certain obstetrical complications. We compared maternal serum SP-1 levels in normal pregnancies ( N = 82), and pregnancies complicated by pre-eclampsia ( N= 37), small for gestational age fetuses ( N = 8) and fetal distress ( N = 13). We also compared levels of this protein in mid-trimester amniotic fluid samples obtained from normal ( N = 47) and small for gestational age fetuses ( N = 25). Despite trends towards low maternal serum and amniotic fluid SP-1 values in complicated pregnancies, there were no statistically significant differences in their levels as compared with normal gestational age matched controls ( P > 0.005). These data do not support the use of SP-1 values in clinical practice.
Published Version
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