Abstract
Objective: The microdose GnRH agonist flare stimulation protocol is widely adopted by in vitro fertilization (IVF) centers for poor responders. However, oral contraceptive (OCP) pretreatment in these cycles could delay or reduce the response in some patients, and compromise the prognosis. When GnRH antagonists were introduced, we speculated that some low responders could benefit from starting gonadotropin stimulation at the beginning of a spontaneous cycle without OCP pretreatment, to avoid the delayed suppression that may occur with OCP. In this study, we compared IVF outcomes in low responders treated with a simple GnRH antagonist stimulation versus a traditional microdose GnRH agonist flare stimulation.
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