Pregnancy rate after ovulation triggering with gonadotrophin releasing hormone agonist versus human chorionic gonadotrophin in women undergoing controlled ovarian stimulation/intrauterine insemination

Abstract

Abstract Background GnRHa is as effective as hCG for ovulation triggering, apart from LH surge, FSH surge is also induced. Objective To compare triggering of ovulation by inducing endogenous LH surge (GnRHa) or using hCG in hMG stimulated cycles for intrauterine insemination (IUI). Setting Prospective randomized study. Materials and methods Out of the three hundred and eighty patients scheduled for IUI, after exclusion of 28 women, 352 were assigned to two groups: hMG/GnRHa (study group, n = 176) were assigned for receiving HP hMG followed by triggering by GnRHa and hMG/hCG (control group, n = 176) were assigned for HP hMG followed by hCG for ovulation triggering. Intrauterine insemination was done using freshly prepared semen 36 h after triggering of ovulation. Luteal phase support was done by 1500 IU hCG, 12 h after the triggering of ovulation. Results LH levels significantly (p Conclusions There is no difference between GnRHa and hCG as regards pregnancy rate in women undergoing hMG stimulation for IUI cycles.