Pregnancy, peripartum, and COVID-19: An updated literature review

Abstract

Due to the physiological changes of the pregnancy and considering the susceptibility of the fetus, pregnant women are among the vulnerable health groups. The current COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has multiplied the health burden on vulnerable and susceptible groups. With over 500,000 new cases daily, the vulnerable groups are in danger more than ever. Therefore, early diagnosis, effective treatment, and efficient prevention strategies are significant among these groups. Since the clinical knowledge about the diagnosis, management, prevention, and many other aspects of pregnancy and lactation during COVID-19 has significantly changed and improved from the pandemic’s beginning, most of the previous knowledge has changed, and the previous publications might not be helpful anymore. This review aims to provide an updated and comprehensive review of the mutual impact of pregnancy and COVID-19 infection, discuss the current controversies based on the most recent findings, and highlight the existing knowledge gaps. Due to the increased susceptibility, undesired outcomes are more expected among pregnant women with COVID-19 infection. Still, prevention measures are the best way of managing COVID-19 in this population. Moreover, further clinical studies should address the long-term complications, outcomes, safety of vaccination, and the impact of the pandemic on mental health.