Abstract
PurposeTo determine the risk of adverse maternal and neonatal outcomes in pregnant women with a hemoglobinopathy trait.Materials and methodsRetrospective cohort study was conducted to compare adverse maternal and neonatal outcomes between pregnant women with a hemoglobinopathy trait (study group; n = 172), and without a hemoglobinopathy trait (control group; n = 360). The medical data were extracted from clinical records of pregnant women attending antenatal care and delivering at the University Hospital Basel or University Hospital Zurich between 2015 and 2018.ResultsA total of 172 pregnant women with a hemoglobinopathy trait and 360 controls were recruited. Apart from fetal acidosis, the groups did not differ significantly in any variables of adverse neonatal outcomes. Whereas, among the maternal outcomes the rate of abortion, gestational diabetes mellitus, bacteriuria or urinary tract infection, intrahepatic cholestasis, abnormal placentation and anemia postpartum were significantly increased in women with a hemoglobinopathy trait.ConclusionIn our study, a hemoglobinopathy trait increased the risk of adverse maternal outcomes but did not increase adverse neonatal outcomes.
Highlights
IntroductionThe most common causes of anemia among pregnant women are iron deficiency and inherited hemoglobin disorders
Anemia is the most common disease in pregnancy and postpartum
The World health organization (WHO) estimates that overall at least 5.2% of the world population carry a significant variant of a hemoglobin disorder; among pregnant women the prevalence is even higher with over 7% [1]
Summary
The most common causes of anemia among pregnant women are iron deficiency and inherited hemoglobin disorders. The World health organization (WHO) estimates that overall at least 5.2% of the world population carry a significant variant of a hemoglobin disorder; among pregnant women the prevalence is even higher with over 7% [1]. Over a number of years, several studies on the effect of a hemoglobinopathy trait on pregnancy have been published. Commonly known that anemia in pregnancy is a significant risk factor of adverse maternal and fetal outcomes, previous studies on the effect of a hemoglobinopathy trait on pregnancy provide controversial results and inconsistent conclusions. Other studies could not verify these increased risks for the fetus among women with a hemoglobinopathy trait [2, 5, 6, 9, 15]
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