Pregnancy outcomes following recurrent miscarriage.

Abstract

Recurrent miscarriage affects 1-2% of the population, and the literature has focussed on causes, treatment, and live birth rate. This study aimed to assess the reproductive outcomes for patients who attended a specialist recurrent miscarriage clinic for investigation and treatment. Prospective analysis of all patients who attended a recurrent miscarriage clinic from January 2014 to January 2021. Of the 488 patients who attended a specialist clinic, 318 had a further pregnancy with 299 included in this study. The median age was 37years, with 55.6% having a previous live birth. The subsequent live birth rate was 75.3%, 22.0% had a further pregnancy loss, 1.7% had an ongoing pregnancy, and 1% attended another institution after the second trimester. The rate of preeclampsia was 2.2%, pregnancy-induced hypertension was 2.2%, fetal growth restriction was 5.3%, preterm birth ≤ 34weeks was 1.8%, and preterm birth > 34weeks < 37weeks was 6.6%. Patients who attend a dedicated recurrent miscarriage clinic for investigation and treatment have a high live birth rate in a subsequent pregnancy. A subsequent pregnancy following recurrent pregnancy loss does not appear to be associated with an increased risk of adverse pregnancy outcomes.