Pregnancy outcomes and placental characteristics of selective intrauterine growth restriction with or without twin anemia polythemia sequence

Abstract

IntroductionTo investigate differences in the pregnancy outcomes and placental characteristics of selective intrauterine growth restriction (sIUGR) with or without twin anemia polythemia sequence (TAPS). MethodssIUGR patients were assigned into two groups based on the occurrence of TAPS. The pregnancy outcomes and placental characteristics were compared. A diameter of ≥2 mm was defined as thick anastomosis. ResultsThe prevalence of artery-to-artery (AA) (45.5% vs 88.6%, P = 0.002) and thick AA (0% vs 53.5%) in TAPS group were lower than non-TAPS group. The overall diameter of AA (0.5 (0.4–1.3) vs 2.5 (0.3–7.1) mm, P = 0.001) in TAPS group was smaller than non-TAPS group. The prevalence of thick artery-to-vein (AV) (0% vs 36.0%) in TAPS group was lower than non-TAPS group. Also, the overall diameter of AV (0.9 (0.6–2.1) vs 4.8 (0.3–17.8) mm, P < 0.001) in TAPS group was smaller than non-TAPS group. The total quantity (2 (1–6) vs 6 (1–16), P = 0.001), and the overall diameter of anastomoses (1.1 (0.6–4.7) vs 7.5 (0.5–22.4) mm, P < 0.001) were smaller in TAPS group than non-TAPS group. The placental territory discordance ratio of TAPS group was smaller than non-TAPS group (0.39 (0.13–0.56) vs 0.56 (0.01–0.88), P = 0.008). The umbilical cord insertion distance ratio in TAPS group was higher than non-TAPS group (0.81 ± 0.12 vs 0.57 ± 0.20, P < 0.001). DiscussionThe placental anastomoses of sIUGR with TAPS were small. sIUGR with TAPS had smaller differences in placental share and larger distances between umbilical cord insertions.