Abstract

Objective To compare the pregnancy outcomes of frozen-thawed blastocyst transfer on different developmental days. Methods Retrospective analysis was performed in the clinical data of 1 176 patients accepting frozen-thawed blastocyst transfer, including 135 cases in preimplantation genetic diagnosis (PGD) cycle. Those patients were sperated into two groups, single embryo transfer (SET) group and double embryo transfer (DET) group. The pregnancy outcomes in the two groups were compared on day 5 (D5) and D6. Results Biochemical pregnancy rate (56.91%), clinical pregnancy rate (53.25%) and multiple pregnancy rate (1.20%) in D5 DET were significantly higher than those in SET group (P<0.05). There was no statistical difference in embryo implantation rate between D5 DET and D5 SET, while they were significantly higher than those in D6 DET group and SET group (P<0.05). With the same level blastocysts and the blastocysts in PGD cycle between D5 and D6 SET in comparison, biochemical pregnancy rate, clinical pregnancy rate and embryo implantation rate in D5 group were significantly higher than those in D6 group (P<0.05). Conclusion In frozen-thawed blastocyst transfer cycle, on the condition of all top-scoring blastocysts, pregnancy outcomes in D5 blastocyst transfer were better than those in D6 blastocyst transfer. Key words: Frozen-thawed blastocyst transfer; Day 5 blastocyst; Day 6 blastocyst; Pregnancy outcome; Preimplantation genetic diagnosis (PGD)

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