Abstract
Bispyribac sodium is commonly used as a herbicide worldwide. Few studies had investigated the health impact of exposure to it. Redox homeostasis has a great role during organogenesis through in cell growth, differentiation, and death. The aim of this study is to investigate the redox homeostasis imbalance and teratogenic effect of BPS in female rats exposed to bispyribac sodium (BPS) during organogenesis and evaluates the protective role of Nigella Sativa Oil (NSO). Pregnant female rats were grouped into four groups, negative and positive (NSO) control groups. While the others, BPS with and without NSO treatment groups. Results showed that BPS exposure during the pregnancy led to maternal and fetotoxicity as evidenced by preimplantation, post-implantation loss, reduction in placenta weight, reduction in fetal weight, fetal length, skeletal anomalies (incomplete ossification, misaligned sternbrae), visceral malformation (anophthalmia, microphthalmia, internal hydrocephaly, and microcephaly) and oxidative stress in dams serum. NSO treatment exhibited amelioration in the aforementioned maternal and fetotoxicity against BPS exposure.
Highlights
Owing to industrial development, the entire populations have been exposed to many chemical substances such as pesticides, and metals
Group III: (NSO), rats were provided with 1 ml/kg/day of N. sativa oil based on the (Mansour, Sangi, et al 2013, Mosbah, Yousef, et al 2016) studies
The data indicated that maternal toxicity as the number of corpora lutea, corpora lutea /litter, the number of implants, placenta weight, and placenta index/dam were significantly declined in rats administered the bispyribac sodium (BPS) at a dose of (4.38 mg/kg/day (LD50/40)
Summary
The entire populations have been exposed to many chemical substances such as pesticides, and metals. Pesticides are regarded as powerful pollution of the environment that has been concerned with birth defects and reproductive failure. Pesticides are well established to traverse the placental barrier and may cause certain modifications in the formation of placental architectures. Placental injury caused by drugs or contaminants results in retardation of fetal development, resorption, or teratogenicity (El Ghareeb et al, 2015). Studies suggest an association between environmental exposure of pregnant women to certain agricultural pesticides and malformation in their fetuses (Peiris-John and Wickremasinghe 2008). Drugs and chemicals given during this period are more likely to cause fetal defects (Gabr et al, 2015)
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