Abstract
There are reports that pregnant women infected with SARS-CoV-2 not only have increased morbidity but also increased complications and evidence of maternal and fetal vascular malperfusion on placental pathology. This was a retrospective study of pregnant women diagnosed with SARS-CoV-2 infection after March 2020. The results of reverse transcription polymerase chain reaction testing and IgM and IgG antibody testing of the amniotic fluid, cord blood, placenta, and maternal blood were confirmed at delivery. Placentas were evaluated histopathologically. The study included seven pregnant women diagnosed with SARS-CoV-2 infection during pregnancy at a mean gestational age of 14.5 weeks. Out of the seven women, five were infected during the first trimester. The mean gestational age at delivery was 38.4 weeks. The reverse transcription polymerase chain reaction results for maternal plasma, cord blood, placenta, and amniotic fluid were negative and IgG antibodies were detected in maternal plasma and cord blood. On placental pathology, maternal vascular malperfusion was found in only one case, fetal vascular malperfusion in four cases, and inflammatory changes were found in two cases. Pregnancy outcomes for women diagnosed with SARS-CoV-2 infection during early pregnancy are positive and it is likely that maternal antibodies are passed to the fetus, which results in a period of immunity.
Highlights
In December 2019, Severe Acute Respiratory Distress Syndrome Coronavirus 2 (SARSCoV-2), a novel coronavirus that has both toxic and infectious properties, first appeared inWuhan, China
Following approval from the institutional review board, we conducted a retrospective chart review of pregnant women infected with COVID-19 during pregnancy who delivered at Keimyung University Dongsan Medical Center, Daegu, Korea after March 2020
The results of this study show that the pregnancy outcomes of women diagnosed with COVID-19 during early pregnancy are positive
Summary
In December 2019, Severe Acute Respiratory Distress Syndrome Coronavirus 2 (SARSCoV-2), a novel coronavirus that has both toxic and infectious properties, first appeared inWuhan, China. On 1 April 2021, there were more than 100 million infections worldwide and more than 2 million deaths [1,2]. This count is increasing daily and the approximate worldwide mortality rate is estimated at 2–3% as reported by the World Health. The infection may be asymptomatic, result in a mild viral syndrome, or cause severe symptoms such as respiratory failure, shock, multi-organ dysfunction, and death [3]. Previous studies of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and SARS-CoV indicate that infections during pregnancy are severe and tend to be associated with poor neonatal outcomes including an increased risk of miscarriage, fetal growth restriction, and preterm birth [4,5,6,7]. Most of the published studies documenting these results involved infection during the second or third trimester of pregnancy and there
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