Pregnancy Outcome and Clomiphene Citrate Dose.

Abstract

Background: Clomiphene citrate (CC) has been shown to result in isomer-specific systemic accumulation of zuclomiphene across consecutive cycles of ovulation induction. Due to prolonged nuclear receptor occupancy and anti-estrogenic activity, it is biologically plausible that CC may influence early embryonic development and lead to higher rates of congenital malformations and spontaneous abortions. Furthermore, there is a paucity of data with respect to adverse reproductive outcome following CC treatment in doses up to 250 mg/day.