Pregnancy outcome analysis of preimplantation genetic testing for women of advanced maternal age

Abstract

Objective To investigate whether preimplatation genetic testing for aneuploidies (PGT-A) can benefit pregnancy outcomes in women of advanced maternal age (AMA). Methods Totally 98 women received PGT-A between January 2015 and May 2017 in Reproductive Medicine Center Shandong University were enrolled, named PGT group. Patients who underwent in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) were matched as control group. The pregnancy outcomes were compared between PGT and IVF groups as well as between PGT and ICSI groups, respectively. We also analyzed the pregnancy outcomes of AMA women who prepared for a PGT-A cycle but changed to fresh embryo transfer because of less than 3 good-quality embryos on day 3 (D3). Results The live birth rate (LBR) per transfer was significantly higher in PGT group (48.44%) compared with IVF (24.00%, P 0.05) between PGT group and control group. The LBR was only 7.14% in AMA women who underwent fresh embryo transfer cancelling PGT-A. Conclusion For women of high reproductive age, PGT-A can significantly improve the LBR, reduce the risk of pregnancy loss and increase the efficiency of transplantation, but it will increase the cycle cancellation rate. Careful consideration is advised when an AMA woman is deciding whether to cancel PGT-A and receive fresh embryo transfer with limited number of D3 good-quality embryos. Key words: Pregnancy outcome; Advanced maternal age; Preimplatation genetic screening; Live birth rate; Pregnancy loss rate