Abstract
A considerable proportion of mice lose acquired immunity to Plasmodium berghei during the first pregnancy. Immune parous mice, however, have a better immune status than virgin mice, the risk of loss of immunity during a subsequent pregnancy is greatly reduced, the capacity to clear parasites is enhanced, and the maintenance of immunity is less dependent on certain splenic functions. The establishment of improved immunity is dependent on the presence of proliferating parasites during the second half of pregnancy when immunosuppression results in recrudescence. Immune reactivity is also improved after a (chemotherapeutically controlled) recrudescent infection provoked by immunosuppressive treatment of immune mice with corticoids or anti-T cell serum. This mimics the situation encountered during pregnancy. Hence, improved immunity after pregnancy is a consequence of a reconfrontation of a suppressed and/or convalescent immune system with proliferating parasites.
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