Abstract
BackgroundWe aimed to investigate whether maternal chronic hepatitis B virus (HBV) infection affects preterm birth (PTB) in pregnant women.MethodsWe retrospectively analyzed HBV-infected and non-infected pregnant women attending antenatal care at Fujian Maternity and Child Health Hospital, Fuzhou, China between January 1, 2016 to December 31, 2018. Participants were divided into HBV infection (n = 1302) and control (n = 12,813) groups. We compared baseline data, pregnancy and perinatal complications, and preterm delivery outcomes between groups. Performed multiple logistics regression analysis to adjust for confounding factors. Finally, we compared early PTB outcome between different HBV DNA level groups.ResultsThe incidence of preterm birth (gestation less than 37 weeks) was similar between the groups, early preterm birth (gestation less than 34 weeks) were significantly more among the HBV infection group than among the controls (1.6% VS. 0.8%; P = 0.003). After adjusting for confounding factors through logistics regression, HBV infection was found to be an independent early PTB risk factor gestation (adjusted odds ratio 1.770; 95% confidence interval [1.046–2.997]). The incidence of early PTB in < 500 group, 500 ~ 2.0 × 10e5 group and > 2.0 × 10e5 group was not statistically significant (P = 0.417).ConclusionHBV infection is an independent risk factor for early PTB, and the risk did not seem to be influenced by the levels of HBV DNA. Comprehensive programs focusing on pregnant women with HBV infection would reduce the incidence of adverse outcomes.
Highlights
Hepatitis B virus (HBV) infection is a global health problem with 2 billion people being infected worldwide, and more than 360 million are carriers of hepatitis B virus (HBV)
Compared the baseline situation of the women who were followed with those who were lost to follow-up or have missing data, we found that there were no significant differences in age, height, prenatal weight, the incidence of previous preterm birth (PTB) history and the incidence of HBV infection between the two groups (Table 1)
Participant characteristics An analysis of the baseline situation between the HBV infection group and the control group found that the two groups of pregnant women had no statistically significant differences in pre-pregnancy Body mass index (BMI), prenatal BMI, previous PTB history, uterine malformation, and the number of prenatal check-up
Summary
Hepatitis B virus (HBV) infection is a global health problem with 2 billion people being infected worldwide, and more than 360 million are carriers of HBV. The morbidity varies greatly in different countries and regions. China is one of the regions where HBV infection is highly endemic [1], the infection rate of HBV in. Zheng et al BMC Pregnancy Childbirth (2021) 21:513 hepatitis B virus DNA and PTB is not yet clear. We aimed to conduct a retrospective cohort study to analyze the relationship between HBV infection in pregnant women and PTB to provide clinical reference for pregnancy supervision and perinatal intervention, and improve the outcome of preterm infants. We aimed to investigate whether maternal chronic hepatitis B virus (HBV) infection affects preterm birth (PTB) in pregnant women
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