Pregnancy and perinatal outcomes of infants born following in vitro maturation treatment

Abstract

OBJECTIVE: The aim of this study was to compare pregnancy and perinatal outcomes of the infants born after in vitro maturation (IVM) treatment in order to evaluate the safety issue of IVM treatment. DESIGN: Retrospective analysis. MATERIALS AND METHODS: Obstetric and perinatal data were collected from all pregnancies after IVM treatment from January 2003 to December 2007. A total of 42 pregnancies and 30 live births with 34 infants were analyzed. Multi-pregnancy, ectopic pregnancy, and miscarriage rates were compared with the outcomes of the same period from the conventional IVF treatment and ICSI treatment cycles. Gestational age, cesarean delivery rates, birth weight, Apgar scores, neonatal and obstertric outcome, congenital abnormalities of the all infants were also compared. RESULTS: There were no differences in multi-pregnancy, ectopic pregnancy, and miscarriage rates in IVM treatment compared with conventional IVF and ICSI treatment groups. Gestational age, cesarean delivery rates, birth weight, Apgar scores, neonatal and obstertric outcome, congenital abnormalities were comparable in IVM treatment with conventional IVF and ICSI treatment. CONCLUSIONS: Present study indicates IVM treatment does not increase multi-pregnancy, ectopic pregnancy and miscarriage rates. Also IVM treatment is not associated with any additional obstetric and perinatal risks.