Abstract

Pregnancy after orthotopic ovarian tissue transplantation using N-Hexyl-2-Cyanoacrylate as a tissue adhesive

Highlights

  • The past four decades have seen substantial improvements in the long-term survival of both children and adults with cancer, leading to the development of the services to optimize long-term health after successful treatment

  • Restoration of ovarian function was observed in all cases between 8 and 24 weeks after the transplantation by the significant decrease in follicle-stimulating hormone (FSH) levels compared to preoperative values (Figure 5)

  • This report describes our experience with the use of N-hexyl-2 cyanoacrylate as a fixation surgical treatment in the transplantation site during ortothopic ovarian tissue transplantation

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Summary

Introduction

The past four decades have seen substantial improvements in the long-term survival of both children and adults with cancer, leading to the development of the services to optimize long-term health after successful treatment. The potential loss of fertility for some cancer survivors is a major concern of patients, and in the case of children, of their parents. As a result of improvements in oncologic treatment, the majority of younger cancer patients are achieving prolonged survival [1]. Loss of ovarian function and fertility is one of the most common long-term adverse effects affecting premenopausal patients treated with chemotherapy and/or radiation therapy. A number of strategies have been developed in recent years to enable these patients to have children using their gametes. When chemotherapy can be postponed, it is possible to use ovarian stimulation to obtain oocytes, which can be frozen in either a fertilized or an unfertilized state [2,3]

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