Pregnancy After Living-Donor Transplantation

Abstract

Successful pregnancy outcomes have been reported after all types of solid organ transplantation (1-7). As immunosuppressive agents and medications for other comorbidities (i.e., hypertension, diabetes, etc.) are required in transplant recipients, concerns for pregnancy in this population include the effects of these medications on the developing fetus. Additional concerns relate to the effect of pregnancy on the well-being of the mother and the transplanted organ. Although there are real risks to the mother, the transplanted organ, and the fetus, successful pregnancies are likely in transplant recipients in the presence of stable graft function and with adequate control of comorbidities (8). Thus far, there does not appear to be an increase in the type or incidence of congenital malformations. Most pregnancies proceed without evidence of graft dysfunction and/or irreversible deterioration in graft function.