Abstract
Investigation was undertaken to determine the difference in safety between combined and sequential preparations of oral contraceptives. 90 pregnancies in 1968 (73 women used sequential types and 17 used combined types) were recorded while using the pill. Using Pearls formula the pregnancy rate for combined preparations was .005 and .0467 for sequential preparations. The results showed 100 times greater risk of pregnancy when taking a sequential treatment. The data revealed that sequential treatment failed considerably more often because of method failure than patient failure. The protection rate of sequential preparation was found to be much better than all other non-oral contraceptives.
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