Abstract
EpigenomicsVol. 5, No. 1 CommentaryPregestational nutrition and the epigenetic landscape in next generations: still an almost virgin land to be exploredMihai D NiculescuMihai D NiculescuDepartment of Nutrition & UNC Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC 28081, USA and UNC Nutrition Research Institute, 500 Laureate Way, Kannapolis, NC 28081, USA. Search for more papers by this authorEmail the corresponding author at mihai_niculescu@unc.eduPublished Online:15 Feb 2013https://doi.org/10.2217/epi.12.70AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: epigeneticsgenesinheritancenutritionpregestationalReferences1 Joss-Moore LA, Lane RH. Epigenetics and the developmental origins of disease: the key to unlocking the door of personalized medicine. Epigenomics4(5),471–473 (2012).Link, CAS, Google Scholar2 Niculescu MD. Nutritional genomics: the need for a unified and comprehensive approach. J. Nutrition Disorder Ther.1,e101 (2011).Crossref, Google Scholar3 Gemma C, Sookoian S, Alvarinas J et al. Maternal pregestational BMI is associated with methylation of the PPARGC1A promoter in newborns. Obesity (Silver Spring)17(5),1032–1039 (2009).Crossref, Medline, CAS, Google Scholar4 Bygren L, Kaati G, Edvinsson S. Longevity determined by paternal ancestors’ nutrition during their slow growth period. Acta Biotheor.49(1),53–59 (2001).Crossref, Medline, CAS, Google Scholar5 Nelson VR, Spiezio SH, Nadeau JH. Transgenerational genetic effects of the paternal Y chromosome on daughters’ phenotypes. Epigenomics2(4),513–521 (2010).Link, CAS, Google Scholar6 Nadeau JH. Transgenerational genetic effects on phenotypic variation and disease risk. Hum. Mol. Genet.18(R2),R202–R210 (2009).Crossref, Medline, CAS, Google Scholar7 Niculescu MD. Challenges in nutrition-related DNA methylation studies. BioMolecular Concepts3(2),151 (2012).Crossref, Medline, CAS, Google Scholar8 Niculescu MD. Epigenetic transgenerational inheritance: should obesity-prevention policies be reconsidered? Synesis2,G18–G26 (2011).Google ScholarFiguresReferencesRelatedDetailsCited ByFolded Futurity: Epigenetic Plasticity, Temporality, and New Thresholds of Fetal Life16 March 2017 | Science as Culture, Vol. 26, No. 3Differential Methylation of the Oxytocin Receptor Gene in Patients with Anorexia Nervosa: A Pilot Study11 February 2014 | PLoS ONE, Vol. 9, No. 2 Vol. 5, No. 1 Follow us on social media for the latest updates Metrics Downloaded 204 times History Published online 15 February 2013 Published in print February 2013 Information© Future Medicine LtdKeywordsepigeneticsgenesinheritancenutritionpregestationalFinancial & competing interests disclosureThe author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.No writing assistance was utilized in the production of this manuscript.PDF download
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