Abstract
Dopamine agonists such as pramipexole and ropinirole reduce symptoms in patients with restless legs syndrome (RLS). However, some patients don't tolerate these drugs, and their long-term use can be associated paradoxically with worsened symptoms (so-called “augmentation”). Gabapentin and pregabalin also attenuate RLS symptoms, and gabapentin enacarbil (a long-acting form of gabapentin) is FDA-approved for RLS. In this trial, …
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