Abstract
Te purpose of the current study was to identify an abuse potential of pregabalin in HIVinfected patients with opioid use disorder long time using pregabaline. A cross-sectional study was performed at the St. Petersburg Center for the prevention and control of HIV and infectious diseases. A cohort of 572 HIV-infected patients with opioid use disorder was examined. 96 patients (16,8% of the entire cohort) used pregabalin. 34 of them agreed to participate in the study. Te pregabalin addiction was diagnosed in 23 of 34 observed HIV-infected patients with opioid dependence. People with opioid dependence and presence of organic brain damage of various genesis (toxic exposure, neurological consequences of trauma or infection) are at risk of development of pregabalin dependence. Te use of pregabalin with for self-medication of opiod withdrawal was registered in 11 patients.
Highlights
Kissin M.Ya.1, Khalezova N.B.1,2, Gibitova E.A.1, Tarnorutskaya A.V.1, Ivanov A.N.2 1 First St
A cohort of 572 HIV-infected patients with opioid use disorder was examined. 96 patients (16,8% of the entire cohort) used pregabalin. 34 of them agreed to participate in the study
The use of pregabalin with for self-medication of opiod withdrawal was registered in 11 patients
Summary
Максимальная продолжительность ремиссии в среднем — 2,6±1,5 (0,25-6) лет. Средняя продолжительность ремиссии в настоящее время составила — 9±9,8 (0,5-24) месяцев. 3. Клиническая картина зависимости от прегабалина у ВИЧ-инфицированных больных с синдромами зависимости от опиоидов. Из 34 обследованных больных, принимавших прегабалин, в качестве причины первичного приема прегабалина 22 пациента (64,7%) назвали совет третьих лиц, 8 (23,5%) — предписание врача, 4 (11,8%) — собственную инициативу. 13 пациентов (38,2%) сочетали употребление прегабалина с наркотиками, из которых 11 человек (32,4%) сочетали препарат с метадоном, а 2 (5,9%) — с метадоном и алкоголем. 21 пациент (61,8%) не сочетали прием прегабалина с наркотиками. Наиболее значимыми для пациентов лечебными эффектами от приема прегабалина являлись: терапевтический эффект в отношении синдрома отмены ПАВ и постабстинентных расстройств (почти 60%) и анальгетический (Табл.). Эффекты прегабалина у ВИЧинфицированных больных с синдромом зависимости от опиоидов
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