Pregabalin Misuse and Abuse: A Scoping Review of Extant Literature

Abstract

Prescribing of pregabalin is increasing worldwide with public health concerns centering on misuse and abuse of prescribed and diverted pregabalin. To describe and map what is known about misuse and abuse of pregabalin, a scoping review of available published literature was undertaken. A scoping review methodology was used to identify and map available literature on misuse and abuse of prescribed and diverted pregabalin. Four themes emerged on the misuse and abuse of pregabalin: (a) abuse potential, (b) prevalence of abuse, (c) risk and predisposition, and (d) consequences of abuse. Fifty-four records were reviewed and charted. Of note was the dearth of research on the topic prior to 2005, with increased interest in pregabalin abuse potential from 2010 onward. Available literature supports concern around abuse potential of pregabalin, especially among patients with a history of substance abuse. Prescribers should adopt more rational prescribing.