Abstract
Pregabalin is a lipophilic analogue of gamma-aminobutyric acid (GABA) and has a similar chemical structure to gabapentin and is more potent than gabapentin. This report documents the case of a 28-year-old male presenting with suicidal attempt by pregabalin intake. The patient had an abnormal PR interval (reversible AV-block). He was managed with general supportive care and symptomatic approach such as discontinuation of the drug, hydration with IV fluids, oxygenation, gastric lavage and activated charcoal administration.
Highlights
Pregabalin has been used increasingly in recent years in the treatment of neuropathic pain, epilepsy and anxiety disorders
Pregabalin is a lipophilic analogue of gamma-aminobutyric acid (GABA) and has a similar chemical structure to gabapentin and is more potent than gabapentin
We report here a case of isolated pregabalin toxicity that was successfully managed with conservative treatment only
Summary
Pregabalin has been used increasingly in recent years in the treatment of neuropathic pain, epilepsy and anxiety disorders. It has been reported in the literature with suicidal attempt and its side effects [1,2]. Pregabalin does not bind to plasma proteins and readily penetrates the blood-brain barrier. It is primarily cleared unchanged by renal excretion with an elimination half-life of approximately 6 hours but is increased in patients with renal impairment and dependents on creatinine clearance [3]. We report here a case of isolated pregabalin toxicity that was successfully managed with conservative treatment only
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