Abstract
Introduction. Prefrontal (PFC) connections play a central role in top-down control and are closely associated with abnormalities in Bipolar Disorder (BD) and Obsessive-compulsive disorder (OCD). PFC fibers travel through the internal capsule (IC) to terminate in the ventral striatum and STN, targets for deep brain stimulation (DBS). Imaging studies demonstrate the existence of hubs, areas that are unusually highly connected and serve to integrate and disseminate information. The ventrolateral PFC (vlPFC) has an important role for top-down control. vlPFC activity abnormalities are linked to BD and OCD. This talk focuses on: 1. the organization of PFC fibers in the IC, highlighting potential DBS therapeutic targets; and 2. Hub locations within in the vlPFC, striatum and STN, areas that integrate across functional domains.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
