Prefrontal Cortex Neuromodulation Improve Gait Parameters in Latinx People Living with HIV

Abstract

Background: Human Immunodeficiency Virus (H.I.V.) infection affects motor and cognitive systems and can lead to impairments in gait and balance. The application of transcranial direct current stimulation (tDCS), particularly to the prefrontal cortex, has shown encouraging results in enhancing cognition and executive functioning in individuals with H.I.V., both in the short and long term. Despite the current research, some experts have suggested that incorporating a task that stimulates higher cognitive centers in conjunction with tDCS may enhance its effects. Purpose: This study aimed to examine the effect of tDCS combined with a tracking task on the prefrontal cortex as a viable treatment for enhancing balance and gait in individuals living with H.I.V. Methods: The study evaluated nine female participants, all living with H.I.V., with an average age of 58.8 ± 4.6. As part of the experiment, each participant's gait was carefully evaluated before and after tDCS treatment to measure any potential changes in their walking patterns accurately. Transcranial Direct Current Stimulation (tDCS) was non-invasively administered to the participants' prefrontal cortex within seven days to investigate its possible effects on brain function. Results: Upon analyzing the data, the results demonstrated significant variations between single and dual tasks in numerous aspects, such as temporospatial, turn, and balance, before transcranial direct current stimulation (tDCS), ultimately shedding light on the potential cognitive difficulties that may arise. Data analysis showed noticeable improvements in various aspects, such as stride length, turn duration, and balance trends, when tDCS was applied. Conclusion: This study's findings suggest that tDCS may improve these parameters. However, it is recommended that treatments be administered over an extended time, which is longer than that observed in this study.