Abstract
The influence of alkaline and the neutral grade of magnesium aluminometasilicate as a porous solid carrier for the liquid self-emulsifying formulation with ibuprofen is investigated. Ibuprofen is dissolved in Labrasol, then this solution is adsorbed on the silicates. The drug to the silicate ratio is 1:2, 1:4, and 1:6, respectively. The properties of formulations obtained are analyzed, using morphological, porosity, crystallinity, and dissolution studies. Three solid self-emulsifying (S-SE) formulations containing Neusilin SG2 and six consisting of Neusilin US2 are in the form of powder without agglomerates. The nitrogen adsorption method shows that the solid carriers are mesoporous but they differ in a specific surface area, pore area, and the volume of pores. The adsorption of liquid SE formulation on solid silicate particles results in a decrease in their porosity. If the neutral grade of magnesium aluminometasilicate is used, the smallest pores, below 10 nm, are completely filled with liquid formulation, but there is still a certain number of pores of 40–100 nm. Dissolution studies of liquid SEDDS carried out in pH = 1.2 show that Labrasol improves the dissolution of ibuprofen as compared to the pure drug. Ibuprofen dissolution from liquid SE formulations examined in pH of 7.2 is immediate. The adsorption of the liquid onto the particles of the silicate causes a decrease in the amount of the drug released. Finally, more ibuprofen is dissolved from S-SE that consist of the neutral grade of magnesium aluminometasilicate than from the formulations containing the alkaline silicate.
Highlights
In the recent years, the adsorption of lipid drug formulations onto porous solid carriers has been the aim of several studies [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16]
Magnesium aluminometasilicates are excipients certified to be used in pharmaceutics, which are manufactured on an industrial scale [16]
Many of other porous carriers of welldefined pore size and much higher specific surface area, i.e., SBA-15 or MCM-41 are synthetized at the laboratory scale so as it may be difficult to use them in commercial technologies
Summary
The adsorption of lipid drug formulations onto porous solid carriers has been the aim of several studies [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16]. The functionality of pharmaceutical mesoporous silicates, such as silicon dioxide, calcium silicate, or magnesium aluminometasilicate in the preparation of solid selfemulsifying (S-SE) drug delivery systems with lansoprazole or gentamycin sulfate of improved bioavailability have been reported [9,10]. The modification of the synthetic silicate surface by amino functional or another alkaline group was found suitable to control the release rate of acidic drugs [16]. The pore size and specific surface area of the solid carrier determined both the drug release rate and the silicate loading capacity [6,9,10,11,15,16]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
