Preformulation: Development of Solubility, UV and FTIR estimation of Phytobioactive Antifungal Compounds Allicin

Abstract

When developing new dosage forms, compatibility tests between excipients and active pharmaceutical ingredients (API) are essential for preformulation. An API’s chemical composition, stability, and bioavailability, as well as its safety and therapeutic efficacy, can all be affected by possible physical and chemical interactions with its excipients. Solid dosage forms are typically less stable than the constituents of their API. Even though testing for API-excipient compatibility is important, there isn’t a universally accepted method for assessing these kinds of interactions. The oily, yellow material that gives garlic its distinct smell is called allicin. It’s a thioester of sulfenic acid. Another name for it is alyl thiosulfinate. Its interaction with proteins containing thiols and antioxidant activity are what give it its biological activity. In the present work various preformulation parameters of allicin was estimated and reported.