Abstract
I appreciate the thoughtful comments of Drs. Bhattacharyya and Gupta concerning our recent article (CHEST 1995; 107:352-57). As noted, the two patient groups differed in FEV1% predicted, 41% vs 31%. The study found that a higher FEV1 gave a higher PaO2 at altitude. The lesser severity of group 1 permitted extension of analysis to a larger range of FEV1 values. Preflight Evaluation-To the Editor: Patients and MethodsCHESTVol. 109Issue 4PreviewDr. Dillard and his colleagues have conferred in their article (CHEST 1995; 107:352-57) that a hypoxemic inhalation test at sea level and hypobaric chamber exposure are compatible predictors for altitude hypoxemia. The two groups of COPD patients were different in their spirometric status (FEV1 for group 1 is 41 ±14% and that of group 3 being 31 ±10%); moreover, the presence of normocapnoea (PaCO2-38.0±4.7 mm Hg) in group 3 with FEV1 ≥1 L (0.97±0.32) appears physiologically difficult to appreciate when a rise in PaCO2 is likely. Full-Text PDF
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