Abstract
Crystallization is one of the most important unit operations in the quality control of pharmaceutical products. For this study, a polymer-induced heteronucleation method was selected to investigate the effect of nylon 66 (PA66), polyester (PET), and polypropylene (PP) films on the crystal growth of paracetamol by coupling experiments with modeling. The result of induction time indicated that the order of induced effect was PA66 > PET > PP > no template. X-ray photoelectron spectroscopy results indicated the different functional groups on the surface of films. The crystal habits and powder X-ray diffraction results indicated that preferential orientation along certain facets occurred for PA66 and PET, and the results of in situ Raman microscopy verified the different concentration trends near different films, which is consistent with the preferential orientation effect of films. The results of molecular simulation indicated that the difference in van der Waals and electrostatic interaction, as well as H-bo...
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