Abstract
Ovarian cancer is a leading cause of gynecological cancer-related deaths in women worldwide. Currently, there are no feasible screening strategies for the early detection of ovarian cancer. In some cases, at the time of diagnosis, the cancer cells are chemoresistant and invasive. While there is no curative treatment of advanced ovarian cancer, our understanding of the disease has significantly advanced in the past decade. This book brings together an international team of experts to discuss these advances in our understanding of ovarian cancer with emphasis on the subtypes, pathological mechanisms, and management. Chapter 1 provides a comprehensive account of rare ovarian tumors. It discusses the pathologic and molecular features of ovarian cancers, highlights the evolution of treatment to modern-day standards, and the landmark trials that contributed to these changes. Chapters 2 and 3 elegantly dissect the role of malignant ascites in ovarian cancer. Ascites is an inflammatory process that induces the abnormal accumulation of a large amount of fluid into the peritoneal cavity of patients with advanced ovarian cancer. The accumulation of malignant ascites in the peritoneum provides a pro-inflammatory tumor-promoting microenvironment for cancer cells and is associated with chemoresistance and poor prognosis. Despite proof that the accumulation of peritoneal fluid signifies poor outcome for ovarian cancer patients, the role of malignant ascites in promoting metastasis. CONTINUE READING…..
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