Preface

Abstract

Abstract Infections with the α-herpesviruses, herpes simplex virus (HSV) and varicella-zoster virus (VZV) are common and are often considered trivial dermatological conditions. They should more appropriately be considered as chronic infections of the sensory nervous system. Reactivation of either virus results in significant discomfort and psychosocial distress, problems that could be minimized by appropriate therapy. Furthermore, the public health impact of genital HSV infection should not be underestimated. These aspects were explored at a symposium held at the Eighth Congress of the European Academy of Dermatology and Venereology, held in Amsterdam in September 1999, the proceedings of which form the basis for this supplement. Four important aspects of HSV and VZV infections are addressed. The first is the true significance to the patient of pain persisting after acute herpes zoster. In spite of the availability of oral antiviral agents, appropriate use of which can reduce the duration of such pain, there are still barriers to early diagnosis and prompt institution of effective therapy. The second contribution discusses the importance of diagnosing genital HSV infection, both in terms of reducing morbidity by appropriate treatment of the symptomatic individual and, in public health terms, to reduce transmission of the virus. The authors recognize both the advantages in using type-specific serology in truly asymptomatic patients as well as any concomitant costs in terms of psychological distress to the individual or their partner. The pathogenesis, epidemiology, diverse clinical presentations, psychosocial impact and management of facial herpes simplex in general are discussed in the third manuscript. The final paper provides an in-depth review of the available data on HSV infection and its prevention in the context of facial resurfacing in cosmetic surgery. Further ideas for improved outcome are considered in this setting, where the natural expectation of excellent results is high. Awareness of the importance and extent of each of these issues should improve the management of many patients. We acknowledge with gratitude the support of Glaxo Wellcome in the production of this publication.