Abstract
The use of computers and computational methods has become ubiquitous in biological and biomedical research. This is driven by numerous factors: one primary reason is the emphasis being placed on computers and computational methods within the National Institutes of Health (NIH) roadmap; and another factor is the increased level of mathematical and computational sophistication among researchers, particularly among junior scientists, students, journal reviewers, and NIH study section members. The rapid advances in computer hardware and software also make these methods far more accessible to the rank–and–file research community. A general perception exists that the only applications of computers and computer methods in biological and biomedical research are either basic statistical analysis or the searching of deoxyribonucleic acid (DNA) sequence data bases. Although these are important applications, they only scratch the surface of the current and potential applications of computers and computer methods in biomedical research. This chapter presents a wide variety of applications that extend this limited perception.
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