Preface

Abstract

Illustrated Pathology of the Bone Marrow is designed to help pathologists and pathologists in training answer the practical diagnostic questions that arise during routine analysis of bone marrow core biopsy specimens. Although emphasis has been placed on the histologic interpretation of the bone marrow biopsy, an attempt has been made to integrate histologic findings with clinical and laboratory features and peripheral blood and bone marrow aspiration morphology. In recent years, integration between morphology, immunophenotype, genetic features, and clinical features has been increasingly used to distinguish between distinct clinical entities. This integrated multiparametric approach forms the basis for the WHO classification of tumors of hematopoietic and lymphoid tissue. As a consequence, morphology, immunophenotype, genetics, and clinical features are integrated throughout the book in an effort to summarize the current best practice of bone marrow interpretation. The illustrative case material in this book has been gathered from several institutions, including Indiana University School of Medicine in Indianapolis, Indiana; the College of Physicians and Surgeons of Columbia University, New York, New York; the City of Hope National Medical Center, Duarte, California; and Stanford University, Stanford, California. A systematic, analytical approach to interpretation of pathological changes is used throughout the book, which will enable pathologists with varying backgrounds and experience to feel confident in their assessment of bone marrow specimens during their routine everyday analysis.