Abstract
The consecutive steps of tumor growth, local invasion, intravasation, extravasation, invasion of anatomically distant sites, and immunosuppression are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment [...].
Highlights
Hyaluronan in Breast CancerHA, the unique nonsulfated GAG, and its CD44 and RHAMM receptors have been strongly implicated in cancer progression
matrix metalloproteinases (MMPs) are endopeptidases characterized by a broad range of substrate specificities and are important in extracellular matrix (ECM) remodeling
Ahmad et al note that the pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense, fibrotic stroma composed of ECM proteins that poses a significant physical barrier that is immunosuppressive and obstructs penetration of cytotoxic chemotherapy agents into the tumor microenvironment (TME) [8]
Summary
HA, the unique nonsulfated GAG, and its CD44 and RHAMM receptors have been strongly implicated in cancer progression. Tolg et al focus on the hijacking of the essential response-to-injury functions of HA by tumor cells to promote their invasion and avoidance of immune detection. This is followed by a discussion of how HA metabolism is deregulated in malignant progression and how targeting HA might be used to better manage breast cancer progression. Koutsakis et al show that sHA fragments attenuate breast cancer cell proliferation, migration, and invasion while increasing adhesion on collagen type I in a manner related to their estrogen receptor (ER) status [2]. Biomolecules 2022, 12, 362 breast cancer cell properties than the nonsulfated counterpart, a deeper understanding of the mechanism of its action could contribute to the development of novel therapeutic strategies
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