Abstract
The last decade has witnessed significant progress in our understanding of the relation between depression and epilepsy. In fact, neurologists are starting to appreciate the need to recognize and treat this psychiatric comorbidity. Advances have been made on understanding the epidemiologic and clinical aspects of this relationship as well as on its neurobiologic and psychosocial pathogenicmechanisms. For example, the long-held concept that depression in epilepsy is a complication of the seizure disorder is now being replaced by the recognition of a bidirectional relation between the two conditions, whereby not only patients with epilepsy are at higher risk to develop depression, but patients with depression are at a higher risk to develop epilepsy. This complex relation has been found to impact in a negative way the response to pharmacotherapy and surgical treatment of the sei-
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