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Abstract
This study was aimed at evaluating the use of oral etoricoxib for preemptive analgesia on the health-related quality of life (QoL) outcome after the extraction of mandibular third molar. The study population consisted of 60 participants that required extraction of a single partial bony impacted mandibular third molar under local anesthesia and met the inclusion criteria. The participants were randomized into two groups. The etoricoxib group orally received 60 mg etoricoxib 30 min before surgery, whereas the control group was given a placebo. The patients were assessed postoperatively after 1, 2, 3, 4, 5, 6, and 7 days using the United Kingdom oral health-related QoL questionnaire and visual analog scale for maximum postoperative pain. The total dose of ibuprofen rescue intake and total number of days the drug was taken were recorded. Surgical removal of impacted teeth had a negative influence on the patient's QoL across various physical, social, and psychological aspects. The scores for postoperative pain in the etoricoxib group were significantly lower than those in the control group on each postoperative observation day. The number of patients without analgesic rescue medication, the average amount, and total number of days emergency analgesics were taken were significantly lower in the etoricoxib group than in the control group. The etoricoxib group showed better QoL score than the control group. Preemptive oral etoricoxib is an effective therapeutic strategy for improving the QoL after surgical removal of the impacted lower third molar.
Highlights
The extraction of impacted mandibular third molars under local anesthesia involves bone and muscle tissue damage, which results in inflammatory complications, such as pain, swelling, trismus, and alveolitis, in the immediate postoperative period [1]
This study was aimed at evaluating the effect of preemptive oral etoricoxib on postoperative pain and quality of life (QoL) measures after third molar surgery
We hypothesized that preemptive oral etoricoxib has a significant positive effect on the QoL of patients
Summary
The extraction of impacted mandibular third molars under local anesthesia involves bone and muscle tissue damage, which results in inflammatory complications, such as pain, swelling, trismus, and alveolitis, in the immediate postoperative period [1]. These complications may significantly lead to deterioration in the quality of life (QoL) during the immediate postoperative period [2]. Preemptive oral etoricoxib is an important factor affecting the frequency and severity of postoperative complications [3,4,5,6,7]. Preemptive oral etoricoxib (120 mg) is effective in providing analgesia after total abdominal hysterectomy, single-level discectomy, and inguinal hernia repair [9,10,11]
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