DETERMINING SPOT URINE PROTEIN / CREATININE RATIO SENSITIVITY IN THE DIAGNOSIS OF PREECLAMPSIA WITH VARIABLES SUCH AS URINE SAMPLING TIME AND WAITING TIME

Abstract

OBJECTIVE: The present study aims to compare the success of spot urine protein/creatinine ratio in predicting 24-h proteinuria with different variables such as urine sampling time and urine wait time before analysis.MATERIAL AND METHODS: The study included 100 pregnant women who were tested for their 24-h urine protein levels and simultaneously checked for spot urine protein/creatinine ratio upon admission to our clinic with a complaint of high blood pressure between March 2014 and December 2017. The pregnant women included in the study were divided into two groups: those with a normal range for the level of 24-h proteinuria and those with an abnormal range for 24-h proteinuria. The success of spot urine protein/creatinine level in predicting 24-h urine proteinuria was assessed in relation to spot urine sampling time, wait time, and patients’ demographic data.RESULTS: The optimal cut-off value of spot urine protein / creatinine ratio for groups with and without proteinuria in 24-h urine was determined to be 0.315 (cut-off). Urine sampling time and wait time before analysis were compared but no statistically significant difference was found.CONCLUSIONS: The spot urine protein/creatinine ratio in pregnant women with suspected preeclampsia may replace testing patients for proteinuria in their 24-h urine. However, according to our study, urine sampling time and wait time before analysis did not affect the sensitivity of the test.