Abstract
Introduction To evaluate the clinical utility of placental growth factor (PlGF) in the management of pregnancies complicated by preeclampsia (PE). Methods This prospective cohort study included women with a risk of developing PE. Blood samples were collected every 4–5 weeks from second trimester until delivery. Plasma levels of PlGF were stratified in very low ( 12 pg/mL but Results A total of 75 women were included, 20 developed PE: the ones with very low plasma levels (n = 12) had a significantly lower gestational age at delivery (p = 0.0003), lower birthweight (p = 0.0009), and higher rate of emergency C-section outside labour (p Conclusion Our data suggest that the decreasing of PlGF levels is associated with worse outcomes. Therefore the PlGF may be useful for risk stratification of pregnancies that require an intensive monitoring or delivery. This single biomarker would simplify the clinical management and would reduce costs. Download : Download high-res image (161KB) Download : Download full-size image
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