Abstract
BackgroundSo far, there exists no golden standard for the treatment of arthrofibrosis (AF) following total knee arthroplasty (TKA). Although pain is a hallmark of AF, nociceptive nerve fibers have never been investigated in affected joint tissue.MethodsA total of 24 patients with osteoarthritis (OA) of the knee (n = 12) and post-TKA AF of the knee (n = 12) were included. Along evaluation of typical clinical signs and symptoms by using the Knee Society Clinical Rating System (KSS), the Knee Injury and Osteoarthritis Outcome Score (KOOS), and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC index), the innervation of joint tissue was studied by semiquantitative immunofluorescence of nerve fibers.ResultsPatients with AF compared to OA had a lower KSS and lower KOOS. In all compartments (anterior, medial, and lateral recesses), the density of synovial sympathetic nerve fibers was significantly higher in OA compared to AF, which was also true for the density of sensory nerve fibers in the medial and lateral recesses. In synovial tissue of the anterior recess of patients with AF compared to OA, the density of nociceptive sensory nerve fibers was significantly higher relative to sympathetic nerve fibers. This was similarly observed in the neighboring infrapatellar fat pad of the knee.ConclusionsSimilar as in many painful musculoskeletal diseases, this study indicates that patients with arthrofibrosis of the knee after TKA demonstrate a preponderance of profibrotic sensory nerve fibers over antifibrotic sympathetic nerve fibers. This could serve as a starting point for AF therapy with specific antifibrotic pain medication or regional anesthetic techniques.
Highlights
There exists no golden standard for the treatment of arthrofibrosis (AF) following total knee arthroplasty (TKA)
It is well known that each kind of manipulation including revision surgery means additional mechanical stress, which is afflicted with a high risk of recurrence of fibrosis [6]
The AF compared to the OA patients demonstrated a significantly reduced knee-related quality of Osteoarthritis of Arthrofibrosis of the knee the knee
Summary
There exists no golden standard for the treatment of arthrofibrosis (AF) following total knee arthroplasty (TKA). Most people experience great benefit with regard to mobility and quality of life even in long-term follow-up after total knee arthroplasty (TKA) [1, 2]. It is well known that each kind of manipulation including revision surgery means additional mechanical stress, which is afflicted with a high risk of recurrence of fibrosis [6]. Increased psychological distress is supposed to be a risk factor for postoperative stiffness in TKA [10]. While these problems are recognized, the etiology of postoperative AF is not well understood
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