Abstract
THE adrenal steroids have attained wide acceptance as therapeutic agents in the treatment of rheumatoid arthritis. The chemical analogue of cortisone, prednisone, has properties that have made the steroid approach even more useful in this field of therapy. Specifically, the retention of sodium and the excretion of potassium in unphysiologic amounts, found during cortisone administration, are avoided with the usual maintenance doses of prednisone.1 , 2 Prednisone can be used in cardiac patients without fear of producing or increasing congestive heart failure and in hypertensive patients when salt restriction is desirable. The hypertensive effect occasionally found with cortisone therapy has been shown . . .
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